dna

Some risk factors for breast cancer — such as diet, exercise or hormone medications — are preventable. But others, like certain genetic mutations, can’t be changed.

It’s already known that some genes can predict the likelihood of breast cancer. Women with a mutation in the BRCA1 or BRCA2 gene, for example, have a 70% risk of developing the disease, according to the American Cancer Society. 

Now, in what they’re describing as a landmark study published in The American Journal of Human Genetics on Monday, researchers have identified a new gene that predicts the likelihood of hereditary breast cancer.

OHIO WOMAN PUSHES PAST BREAST CANCER, WON’T LET DIAGNOSIS SLOW HER DOWN

People who have mutations in a gene called ATRIP are at a significantly higher risk of developing the disease, researchers said.

ATRIP mutations, though, aren’t as prevalent as the ones that can occur in the BRCA1 or BRCA2 genes.

The ATRIP gene’s job is to prevent something called replicative stress, which is a big driver of cancer development.

That’s according to Dr. Jenn Simmons, a functional medicine physician and integrative oncologist at Real Health MD in King of Prussia, Pennsylvania, explained to Fox…

Sir David Jason has discovered he has a daughter he didn’t know about after agreeing to do a paternity test.

The Only Fools and Horses actor, 83, shared his revelation and joy at being the father of a 52-year-old woman and grandfather of a 10-year-old boy in an interview with The Mirror.

But what exactly is a paternity test and how does it work?

What is a paternity test?

A paternity test is a type of DNA test.

“It allows you to check a sample of your DNA against someone who is your [alleged] father, via a mouth swab which is then tested and analyse in a lab,” explains Dr Hana Patel, also a GP expert witness.

This can be done to establish or confirm proof of the biological relationship (or disprove it). The same can be done for a maternity test, which is done using a DNA sample from the mother.

How does a paternity test work?

Once the swab is taken, the lab analysis will “look at genetic markers that are accurate in demonstrating a paternal (or maternal) relationship,” says Dr Patel.

Both the alleged parent and offspring need to do the test as it compares these genetics “between the two for a certain number of matches to show if they are related”.

As every person inherits half of their DNA from their father (and half from their mother), this comparison will be used to help establish how much DNA the…

NILES — The man who snatched a purse and knocked a woman down outside a downtown Niles church has pleaded guilty to a charge of unarmed robbery. 

Antoine Lamar Dallas, 33, of South Bend, was in Berrien County Trial Court Monday afternoon for a status conference when he agreed to plead guilty. He had been set to go to trial next month on the unarmed robbery charge as well as other charges of stealing or retaining a financial transaction device and being a habitual offender. 

Monday, Berrien County Assistant Prosecutor Kate Arnold and defense attorney Kaitlin Locke put the plea agreement on the record. In exchange for pleading guilty to unarmed robbery, the other two charges will be dropped. 

Dallas is scheduled to be sentenced June 5 at 8:30 a.m. in Berrien County Trial Court. The unarmed robbery charge carries a maximum penalty of 15 years in prison and Locke said 

The purse snatching took place outside of the New Journey United Methodist Church at Third and Cedar Streets on April 14, 2022. Dallas was riding a bike past the church and grabbed the purse of an 80 year old woman. She fell down in the incident. Dallas…

• A judge ruled Monday that DNA evidence can’t be mentioned at Trump’s upcoming rape trial.

• E. Jean Carroll sued Trump for defamation and battery over her claim he raped her in the mid-1990s.

• The case is headed to trial in Manhattan federal court next month.

The judge presiding over E. Jean Carroll’s rape and defamation lawsuit against former President Donald Trump has banned lawyers from even mentioning DNA evidence in front of the jury when the case goes to trial next month.

US District Judge Lewis A. Kaplan ruled Monday that both sides would be “precluded from any testimony, argument, commentary or reference concerning DNA evidence” during the trial, which is scheduled to begin April 25.

Kaplan’s order brings to an end a yearslong fight between Trump and his rape accuser over DNA on the dress she says she was wearing when she alleges Trump assaulted her in a Bergdorf Goodman dressing room in the mid-1990s.

Carroll’s lawyers had the dress sent out for forensic testing when she sued Trump in 2019, and unidentified male skin fragments were found. Carroll’s lawyers asked Trump to submit a DNA sample to test against the samples found on the dress, but for years, he refused.

When Trump brought Joe Tacopina onto the case earlier this year, the new attorney made a last-minute offer to submit Trump’s DNA sample. But the discovery period to exchange…

Introduction

Retinoblastoma is the most common, pediatric primary intraocular malignancy. It arises from a mutated Retinoblastoma gene (Rb), a tumor suppressor gene found in chromosome 13 that regulates the cell cycle. A non-mutated retinoblastoma gene contains two non-mutated RB1 alleles. Since tumor suppressor genes only need one copy of the allele to function, tumorigenesis happens when both copies of the RB1 allele are mutated in the same retinal cell (two-hit hypothesis). The tumor cells of a person with retinoblastoma have a nonfunctional RB1 gene, this allows for dysregulation of the cell cycle and unregulated growth in those cells.^1–3 The mutations rendering an RB1 gene nonfunctional can be either sporadic or inherited.⁴ Sporadic mutations are de novo modifications in somatic cells, while inherited mutations are modifications in gamete or sex cells that can be passed onto offspring. In heritable or familial retinoblastoma, a dysfunctional RB1 allele is directly passed down from the biological mother or father to the embryo. In this case, a child has already inherited a mutated RB1 allele, and only an additional, single sporadic mutation is needed to induce tumorigenesis.

Risk Factors and Incidence

Retinoblastoma is the most common pediatric intraocular malignancy with an incidence of 1 case per every 15,000 to 20,000 live births and 9000 newly diagnosed patients every year worldwide.² The presence of a mutated RB1 allele predisposes the child to developing…

A convicted felon and former handyman, Kenneth Roth, was convicted in the 2009 killing of 61-year-old Ohio nurse Linda Smith, who was found strangled to death in her Osnaburg Township home during a welfare check.

The accused was linked to the murder using YSTRA DNA found on the victim’s underwear. The latter had hired him to help around the house, especially for moving furniture and yard work.

Reports state that Kenneth Roth, who had previously served time for s*xual assault and murder related charges, was sentenced to life in prison without the possibility of parole in 2017. He was reportedly serving his sentence at the Marion Correctional Institution when he died of COVID-19 in April 2020.

An upcoming episode of ID’s Evil Lives Here is scheduled to revisit Linda Smith’s more-than-a-decade old case. The episode, titled Nobody Believed Me, airs on the channel this Sunday, March 26, at 10:00 pm ET, whose synopsis reads as:

“When Matt Roth is just a boy, his stepfather brings him along on handyman jobs; he thinks he is just there to help his dad, but he doesn’t realize he is walking into the scenes of brutal murders.”

Kenneth Roth was questioned about the deaths of three other women during…

Duff interviews the star testimony in Cantu’s case that sent him to death row. Also, the podcast shares the early jail tapes to hear first-hand conversations with Cantu and his family during his initial arrest.

The jail tapes embody the frustration in Cantu’s voice in 2000 as a man fighting for his life behind bars with an ill-equipped defense team and a family naive to the Texas criminal justice system nor the financial means to stand a chance. 

The podcast sheds light on Cantu’s defense team during the murder trial. The state utilized five experts; the state-appointed defense requested zero experts. The podcast shows that the…