, 2022-08-03 18:06:00,
The genes involved in coronary heart disease, the most common form of heart disease, appear to be nearly the same for everyone, according to a VA study.
Roughly one-third to one-half of everyone’s chances for developing this type of heart disease are rooted in their genes. This genetic risk seems to be the same across all major racial and ethnic backgrounds, including people of European, African, Japanese, and Indigenous ancestries, the VA study found.
Some groups, such as African Americans, are more likely to suffer from heart disease, and our findings indicate that’s not because they have a higher genetic risk for the disease. It confirms that other factors are responsible for more heart disease in those populations, such as access to health care and different lived experiences,” she adds.
Dr. Catherine Tcheandjieu, study author, genetic epidemiologist, VA Palo Alto Health Care System and University of California San Francisco
The genetic study-;the largest to date on heart disease-;was published August 1, 2022, in Nature Medicine. It looked at nearly a quarter of a million cases of coronary heart disease, including more than 100,000 U.S. Veterans with the disease.
Coronary artery disease is the leading cause of death in the United States, responsible for one in every five deaths. It occurs when major blood vessels to the heart muscle become narrowed or blocked, which can lead to heart attack.
The study was led by investigators at the Palo Alto VA and involved researchers from several other VAs across the nation.
Research into the genetics of heart disease, like many other areas of health research, is mostly based on data from white people because of higher participation.
The Nature Medicine study, on the other hand, examined the genes of more than 27,000 Black and 12,000 Hispanic people with coronary artery disease. Most of these were Veterans, who agreed to share their genetic and health information for research as part of VA‘s Million Veteran Program, also known as MVP.
With data from MVP, VA researchers in this study confirmed for the first time that many genetic variations known to heighten heart disease risk in white people have the same effect in people of African and Hispanic ancestry. Additionally, researchers found nearly 100 new locations on the human genome where variations appear to increase risk of coronary artery disease.
To find these locations in the human genome that are linked to heart disease,…
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