More adjuvant treatment decisions are being driven by molecular profiling for patients with endometrial cancer with POLE mutations, mismatch repair (MMR) status, and other genetic alterations dictating the best course of therapy, according to Ritu Salani, MD, MBA. She added that testing can lead to better outcomes while reducing toxicities by optimizing treatment selection.

“We’re now moving to a molecular landscape, and profiling is helping to inform treatment strategies. [We are] exploring this further and hopefully personalizing medicine for the first time in this disease,” Salani said in an interview with OncLive^® following a State of the Science Summit^™ on women’s health.

Salani discussed the continued evolution of molecular profiling in endometrial cancer, advances in immunotherapy for endometrial and cervical cancer, and ongoing research in gynecologic cancers. Salani is the director of the Division of Gynecologic Oncology and a professor of Obstetrics and Gynecology at the University of California, Los Angeles (UCLA), Jonsson Comprehensive Cancer Center.

OncLive^®: How has the use of immunotherapy evolved in endometrial cancer?

Salani: It was exciting talking about endometrial cancer, where immunotherapy has changed the landscape regarding treatment. Studies have gone from looking at the recurrent setting and [immunotherapy] in combination with lenvatinib [Lenvima], to now pushing [these regimens] into the frontline. Although we’re waiting for these trials to…