Inside Fred Witherspoon’s house, the phone rings off the hook.

His wife, Renee, starts the car to pick up a relative from the airport as Fred answers call after call from family members. The T-shirts are ordered, the food is prepared and the itinerary is set.

Family is coming over — the whole family.

It’s been this way almost every July since 1962 — minus one year when they were saving up for a big family reunion cruise.

Fred’s grandparents, family patriarch Rev. Willie Witherspoon and matriarch Daisy Strain Witherspoon, started the tradition in their home base of Lancaster, S.C., as a way to connect the two families and stay in touch. The early years saw up to 300 people attend.

The reunion location moves around from year to year. They’ve met everywhere from Pennsylvania to Nevada to…