Children |
| 1. Henrietta Clay, b. 25 June 1800, Lexington, Fayette County, Kentucky, United States of America d. 14 June 1801, Lexington, Fayette County, Kentucky, United States of America (Age 0 years) |
| 2. Theodore Wythe Clay, b. 3 Jul 1802, Lexington, Fayette County, Kentucky, USA d. 5 May 1870, Lexington, Fayette County, Kentucky, United States of America (Age 67 years) |
| 3. Thomas Hart Clay, Sr, b. 22 September 1803, Lexington, Fayette County, Kentucky, United States of America d. 18 March 1871, Lexington, Fayette County, Kentucky, United States of America (Age 67 years) |
| 4. Susan Hart Duralde, b. 14 February 1805, Lexington, Fayette County, Kentucky, United States of America d. 18 September 1825, New Orleans, Orleans Parish, Louisiana, United States of America (Age 20 years) |
| 5. Mary Ann Brown Erwin, b. 15 April 1807, Lexington, Fayette County, Kentucky, United States of America d. 10 December 1835, Lexington, Fayette County, Kentucky, United States of America (Age 28 years) |
| 6. Lucretia Hart Clay, b. February 1809, Lexington, Fayette County, Kentucky, United States of America d. 18 June 1823, Lexington, Fayette County, Kentucky, United States of America (Age ~ 14 years) |
| 7. Henry Clay, Jr, b. 10 April 1811, Lexington, Fayette County, Kentucky, United States of America d. 22 February 1847, Buena Vista, Acuña Municipality, Coahuila de Zaragoza, Mexico (Age 35 years) |
| 8. Eliza Hart Clay, b. 5 July 1813, Lexington, Fayette County, Kentucky, United States of America d. 11 August 1825, Lebanon, Warren County, Ohio, United States of America (Age 12 years) |
| 9. Laura Clay, b. October 1816, District of Columbia, District of Columbia, United States of America d. December 1816, District of Columbia, District of Columbia, United States of America (Age ~ 0 years) |
| 10. James Brown Clay, b. 9 November 1817, Washington, District of Columbia, District of Columbia, United States of America d. 26 January 1864, Montreal, Montreal Region, Quebec, Canada (Age 46 years) |
| 11. John Morrison Clay, b. 21 February 1821, Lexington, Fayette County, Kentucky, United States of America d. 10 August 1887, Lexington, Fayette County, Kentucky, United States of America (Age 66 years) |
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