Isham married Mary Ann "Polly" Sanders on 10 Feb. 1842 in Pike County, Kentucky, USA. Mary was born in 1825 in Pike, Kentucky, United States; died on 13 Mar 1876 in Wise County, Virginia, USA. [Group Sheet] [Family Chart]

1. Margaret Elizabeth Mullins was born on 18 Aug 1843 in , Russell, Virginia, USA; died in 1915 in , Pike, Kentucky, USA.
2. Sarah Mullins was born on 20 Sep 1846 in Russell, Virginia, United States; died on 10 Mar 1913 in Clintwood, Dickenson, Virginia, United States.
3. Mahulda "Hulda" Mullins was born on 25 Dec 1847 in Russell, Virginia, USA; died about 3 Oct 1896 in , Pike, Kentucky, USA.
4. Nancy Margaret Mullins was born on 25 Aug 1849 in , Russell, Virginia, USA; died on 13 May 1926 in Pike, Kentucky, USA.
5. Spencer Mullins was born on 1 Jan 1852 in , Russell, Virginia, USA; died on 22 Aug 1921 in Clintwood, Dickenson, Virginia, USA.
6. Wilson Mullins was born on 15 Oct 1854 in Russell, Virginia, United States; died on 4 Jan 1855 in Russell, Virginia, United States.
7. Preston Press Mullins was born on 19 Feb 1857 in , Wise, Virginia, USA; died on 19 Jul 1928 in Trammell, Dickenson, Virginia, USA.
8. John "Flat John" Mullins was born on 18 Feb 1858 in , , North Carolina, USA; died on 27 Feb 1936 in , Dickenson, Virginia.
9. Mary Ann "Polly" Mullins was born on 15 May 1861 in Wise, Virginia, USA; died on 24 Mar 1940 in Clintwood, Dickenson, Virginia, USA.
10. Surilda "Rilda" Mullins was born in Aug 1862 in , Wise, Virginia, USA; died on 16 May 1928 in Pike, Kentucky.
11. Marshall Mullins was born in 1864; died in 1864.
12. Hannah Minerva Mullins was born on 14 Mar 1866 in Virginia; died on 2 Sep 1934.
13. Noah Fuller Mullins was born on 26 Aug 1867 in Wise, Wise, Virginia, United States; died on 10 Jan 1940 in Virginia, United States.
14. Isom Mullins was born on 13 Oct 1870 in Cintwood, Wise, VA; died on 16 Sep 1919 in Dickenson, Virginia, United States.

Isham married Elizabeth "Betty" Vanover in 1853. Elizabeth (daughter of Cornelius Vanover, VI and Sarah Cooley Hill) was born about 1834 in Ashe, North Carolina; died on 14 Aug 1901 in Clintwood, Dickenson, Virginia, USA. [Group Sheet] [Family Chart]

1. Harvey Mullins Vanover was born on 7 Jul 1853 in Russell, Virginia, USA; died on 12 Jun 1925 in Marion, Smyth, Virginia, USA; was buried in Clintwood, Dickenson County, Virginia, United States of America.

Isham married Mary Caroline Phipps on 29 Apr 1878 in , Wise, Virginia, USA. Mary (daughter of David Cox Phipps and Charlotte Lottie Long) was born on 05 Sep 1851 in Russell, Virginia, United States; died on 4 Sep 1905 in , Dickenson, Virginia, USA. [Group Sheet] [Family Chart]

1. Amanda Jane "Mandy" Mullins was born on 26 Jan 1879 in Wise, Wise, Virginia, USA; died on 19 Feb 1963.
2. Louisa V. Mullins was born on 17 Aug 1881 in , Dickenson, Virginia; died on 4 Aug 1963 in Athens, Athens, Ohio, United States.
3. Creed Mullins was born in 1883 in , Dickenson, Virginia; died in 1886 in , Dickenson, Virginia.
4. Lowry G. Mullins was born on 30 Jun 1885 in , Dickenson, Virginia, USA; died on 10 Aug 1921 in , Dickenson, Virginia, USA.
5. Media Ellen "Meady" Mullins was born on 13 Jul 1887 in Dickenson, Virginia; died on 14 Oct 1946.
6. Ida Mae Mullins was born on 4 Feb 1890 in Dickenson, Virginia; died on 28 May 1912 in Virginia, United States.

Marshall married Sarah Sallie Potter Little on 19 Sep 1811 in Floyd, Kentucky, United States. Sarah (daughter of Isaac Little and Winnie Caudill) was born about 1800 in Virginia, USA; died on 22 Nov 1877 in Pound, Wise, Virginia, United States. [Group Sheet] [Family Chart]

Ambrose married Nancy Judith Stanley in 1777 in wias, Virginia, United States. Nancy (daughter of William Stanley, III and Nancy Mullins) was born in 1795 in Wise, Wise, Virginia, United States; died in 1860 in Pound, Wise, Virginia, United States. [Group Sheet] [Family Chart]

Isaac married Winnie Caudill in 1781 in Virginia, United States. Winnie was born in 1750 in Virginia, United States; died in 1855 in Pike, Kentucky, United States. [Group Sheet] [Family Chart]

William married Katherine Elizabeth Varner in Abt. 1742. Katherine (daughter of Johann Adam Werner and Catherine Barbara SIGLER) was born in 1729 in Martinsville, Henry, Virginia, United States; died in 1825 in Halifax,,Virginia,USA; was buried in Henry, Franklin County, Virginia, United States of America. [Group Sheet] [Family Chart]

William married Nancy Mullins in 1770 in Virginia, USA. Nancy was born in 1750 in Pittsylvania, Virginia; died on 15 Jan 1849 in Franklin, Virginia, USA. [Group Sheet] [Family Chart]